As community members in an Appalachian town become sick, the source of the contagion is called into question. Fallout follows three individuals experiencing illnesses after exposure to environmental contamination from a nearby facility.

Fallout examines how rural manufacturing perpetuates the cycle of exploitation and environmental contamination that has inundated the Appalachian region for decades. The film incorporates digital footage as well as over 600 feet of 16mm film processed with contaminants from the facility.